University:
Northwest College
Course:
VN 210 | Introduction to Pharmacology
Academic year:

2023
Views:

370

Pages:

2
Author:

Yesenia M.

CONJUGATED ESTROGENS (CENESTIN, ENJUVIA, PREMARIN) Therapeutic class: hormone Pharmacologic class: estrogen; hormone replacement therapy Actions/uses: conjugated estrogens contain a mix of different natural estrogens. Primary indication for conjugated estrogens has been to tx mod to severed symptoms of menopause caused by diminished estrogen secretion by the ovaries. Topical preparations can be used to tx s/s associated w menopause such as vulvar or vaginal atrophy and dyspareunia (painful intercourse) Other replacement therapies include tx of : female hypogonadism and use after oophorectomy. Also approved for palliative tx of prostrate cancer and some types of breast cancer Conjugated estrogens have several positive metabolic effects, including an increase in bone density and a reduction in LDL cholesterol. Can also lower r/o CAD and colon cancer ADMINISTRATION ALERTS: use a calibrated dosage applicatior for admin of vaginal cream For IM or IV admin, reconstitute by first removing approx. 5ml or air from the dry powder vial then slowly injecting the diluent into the vial Admin IV push slowly at a rate of 5mg/min PREGNANCY CATEGORY X Onset: Unknown Peak: Unknown Duration: Unknown A/E: nausea, fluid retention. Edema, breast tenderness, abdominal cramps, bloating, acute pancreatitis, appetite changes, acne, mental depression, decreased libido, HA, fatigue, nervousness, weight gain. A/E are dose dependent and increase in pts 35 or older. BLACK BOX WARNING: estrogens associated w higher risk of endometrial cancer in postmenopausal women Using w medroxyprogesterone increases the risk of breast ca. When used alone. Estrogens increased the risk of stroke, DVT, MI, PE, and dementia CONTRAINDICATIONS: don’t give to pregnant pts Don’t give to women w known or suspected carcinoma of the breast or other estrogen dependent tumors INTERACTIONS: decreased effect of tamoxifen Enhanced corticosteroid effects Decreased effects of anticoagulants , especially warfarin Effects of estrogen can be decreased if taken w barbiturates or rifampin Increased effect of TCAS Tx of overdose: NONE