University:
Northwest College
Course:
VN 210 | Introduction to Pharmacology
Academic year:

2023
Views:

101

Pages:

2
Author:

Yesenia M.

Digoxin-gen →Cardiac glycoside (Lanoxin (Lanoxicaps) trade think digoximit (cardine) Therapeutic class: prig for HE Pharmacological class Cardiac glycoside actions/uses: ↑ contractility or stregth of myocardial contraction. (+ Ihotropic action) accomplished by inbiblting Nat,k, ATPase -as Not accumulates, calcium ions are released from their storage areas in cell. Release of CA lons Produces a more forceful contra of the myocardial fibers. ↑ contractility = cardiac outent = allenate sis of HE and Improns exercise tol. Turme production and ↓ in bloodro)- (disirable range) = relieving destressing als of pulm. congestion and peripheral edema -affects impulse conduction of d. - suppressas SA node and sloves electrical conduction through the AV node (sometimes used to tx dysrhythmias) admin Alerts: Jake arical pulse I full min, hote rate/iny the auality. <60 Hold dose. Notily Imp Check digoxin Ivi before admin 21 yng/mL hold dose. Notify mo - -caution & old/peds dit & renal / hep met enzyme activity. Pregnancy CAT: A LaBS: Unknown Onset: 30-60 min po 5-30 min IV ale: most senous-aystnyminius or (kD. 2 careful use of given I diuretics = Hypokukemia Peak 4-6HRS PO 1.5 HRS IV NIV, fatigue, anorex 19, Visual disturbances, seeing lIALOS, Yellow green tinge blurring. Duration -Bdays Contraindications pts tAv block or ventricular dysrhythmias Unrelated to MF-can worser -older adults = ↑ incidence of ale -Pts TCKD=&dose ble its excreted by this route -caution ifuse tots tmi, cor pulmonale, hypothyroidsm Interactions. Drugs interacts many drugs! I diuretics-hypokalemia and 1 rto dysrtiythmias TACET'S /Spironolactone/K' Supp - hypu kalemia and digoxin contractility. Tither inotropic dregs can cause additive effects in Beta blockers-bradycard 19 I antacids and cholesterol lowering drugs vabsorption of digoxil I IVCA -↑r/o dystythmias (amything Co = rit issues) Quinidine verapamil, amiodorane, alprazolam-distribution and exirction of algoxin = ↑ digoxin toxicity Herbal/Food Kt supp or kt salt substitute should be taken TX overdose: overdose can be fatal. IV infusion of digoxin immune fab (Digibind) het antibodies Specific for