University:
Northwest College
Course:
VN 210 | Introduction to Pharmacology
Academic year:

2023
Views:

398

Pages:

2
Author:

Yesenia M.

hydralazine same ti ad's directly on Smooth muscle Direct acting Vasalilator Direct, arterie acting vasoon Laror. dose: po 10-50ing Lid Therapeutic class Drug for HTN and Hear failure Pharmacological Class: Direct acting vasodilator max: 30mg/day achonsluses: One of the firstoral antiHow drugs. -alts through a direct vasodialation of arterial smooth muscle, hus & effect on veins (acts on arteries!) - begun t low doses, which are gradully increased until the therapeutic response is obtained. -atter months of therapy, tol is developed and dose may need to be f. -Hydralazine has been largely replaced ble of safety concems. *parenteral formulations of hydralacune are for the th of hypertensive emergency.* -BIDil is a fixed-dose combination of liydralazine T isosorbide dinitrate-combo used to tx HE in African Amencans, who show enhanced response to this medication. -abrupt withdrawal may cause Rebound HTN anxiety Pregnancy CAT: C onset: 20-30mins Po 10-30 mins Im 5-20 mins IV Peak: 1-2HK Polim Duration: 3-8 HR PO 30-45 mins IV 1-AHR IV (can be giva polim liv direct (arteng) acting vasodilator: * ale: HA, reflex tachychardia, palpitations, flushing, nausea, diarrhea (common 5/5) Receive beta-Adrenergic blockers to counteract reflex tachycardia. (If Bp, beats faster in an allempt to raise it.) -rare: may produce lupus-like syndrome that may persist for bt months. - Na' and Fluld retention potential ale. Contraindications: in pts tanging rheumatic mitral valve disease blk of its effect on the * pts lupus = worsening sis. * Interactions: drag: severe Hypotension (tother Itumeds) -NSAIDS ATN effects labs: False-positive coombs test Herbal/Food: Hawthorneause additive hypotensive effects Tx for overdose: most likely sign of overdosage is hypotension Txt vasopressor / Iv fluids. other vasodilators: Isosorbide acts on veins, arteries