University:
Northwest College
Course:
VN 210 | Introduction to Pharmacology
Academic year:

2023
Views:

308

Pages:

2
Author:

Yesenia M.

Procainamide-CLASS 1 antidysrhythmics (Sodum channel blocker Therapeutic class Class IA antidysrhythmle Pharmacological class: Sidium channel blocker. [procai Na'mide Nat channe blocker. actionsluses (Chemically rit anesthetic procaine) -Blocks Nat lon channels in myocardial cells, thus reducing automaticity and Slowing conduction of the action potential across the myocardium=prolonged refractory penad = able to suppress dysrhythmias (can correct atrial/ventricular dysrhythmias) -IV or im. Therapeutic serum drug level: 4-8 mcg/ml delays repolarization -use surine Position during vadmin blu severe hypotension may ocuy. Pregnancy CATC procainamide-admin in supine position.... orset: IV immediate peak. 1-1.5 HRS Duration: 3-4HRS. Im 10-30 mins. ale: nlv, abd pain, Hypotension, HA/ HIGH doses = ONS effects confusion psychosis BLACK BOX WARNING prolonged administration=1 titer of antinuclear antibodies (ANA'S) Lupus-like syndrome may occur in 30-50%. pts who take it flyr. Use for life threathining dysrhythmias only bic it can produce new dysrhythmias worsen existing ones. or Agranulocytosis bone marrow depression, neutropenia, hypoplastic anemia, and thrombocytopenia have been reported thin 3 first months of therary. -monitor CBC and dic if signs of blood dyscrasial blood disorders) Contraindications: pict complete Au block (Serere HF blood dyscrasias, myasthema grams. interactions: drigs: I antidysthythmics = additive cardiac depressant effects I anticholinergic drugs = additive anticholmergk sle. LAB Tests. PAST, ALT, ALP, LDH, bilirubin. False(1) coombs test and ANA titers. Herbal/Food: TX overdose: Hypotesion to vasopressurs +x/preventing procainamide Induced dysrhythmias anticholinergic effecrs: Inhibit the parasympathet NS by blocking the binding of Ach to its receptor nerve cells