University:
Northwest College
Course:
VN 210 | Introduction to Pharmacology
Academic year:

2023
Views:

192

Pages:

2
Author:

Yesenia M.

Spironolactone-(Gun) - Potassium-sparing (Aldactone) trade diuretic Therapeulk class Antihypertensive, drug for reducing edema pharmacologic class Polassium-spanng diurenc, aldosterone antagonist Achon/uscs: most frequent ex Potassium-sparingdivietic used to tx mild HIN. (used in combo I other antilt in meds.) -used to reduce edema Produce Think aldosterone keeps NA+ -Slows HF. Xéreduces mortality) * mild diuresis only) VAID=ING! *It Inhibits Aldosterone (Hormone rest for renal absorption of Nat in exchange for Ki,causing water retention Def (excrchion of Nar Tretention of KT) - B/C anthicte of aldosterone effect," Can tx hyperallosterism. *give po with food to ↑ absorption *Do give k+ Supplements! Pregnancy CAT C Onset: 2-4hrs peak: 6-8HKS- Duration: 2-3 days/longer close: PO 25-100mg 1-2 times/day *(max 400mg/494) *Spare 25 or 100(mg) dany matthare is $400 (ag), dary Ale: Hyperkalemia can result allt potassium-sparing effect. (risk↑ Supplements or ACE inhibitors) Hyperkalemia muscle weakness, fatigue, bradycardia In men: gynecomastra (man boobs) Impotence diminished libido Spironolactone Causes sle in the "paird women menstrual irregulanties hirsutism, breast tenderness. BLACK BOX WARNING found to cause tumors in animals in clinical Studies, only use in specified indications. Spironolac Tone Tumors. Contraindications: ahuria, serious CKD, Hyper kalem la Pregnancy/lactation. Interactions ASA and salicylates can ↑ ki levels → can lead to spironolactone Pancity. ;-Conuirment use digoxin, may & digoxin effects -use I kt supp, ACE inhibitors, ARB's (angiotensin-receptor blockers Hyperkalemia (1) -use I other HTN meds/diuretics can Thypotension. LABS plasma cortisol levels interferes glucose Herbal/Food: Hawthorn ↑ hypotensive effects. Overdose tx: NS to replace fluid/electrolyte Vasopressor (norepi) ↑ Bip