University:
Swansea University
Course:
PM-139 | Human Physiology 1
Academic year:

2023
Views:

55

Pages:

3
Author:

Amal J.

Still's disease Definition: Is a form of arthritis that is characterized by high spiking fevers and salmon-colored rash. It is a systemic inflammatory disease (autoimmune disease), and is common in children and less common in adult. Triad signs: - high spiking fever - joint pain - salmon-colored rash It may produce complication in kidney pulmonary and cvs. It is a type of juvenile rheumatoid arthritis and is also known as systemic-onset juvenile idiopathic rheumatoid arthritis (SOJIRA). Clinical features: - high fever (>140°F), rapidly returns to normal or below - salmon-coloured rash (comes and goes and usually doesn't itch) - swelling of the lymph nodes - enlargement of spleen and liver - sore throat - pleuritis - pleural effusion - pericarditis - pericardial effusion - it may develop joint pain and swelling Polyarticular arthritis Diagnosis: Major: fever at least 39°c for I week; arthralgia or arthritis for 2 weeks; salmon-colored rash; leukocytosis (10.000/ml or greater). Minor: sore throat; lymph adenopathy; hepatomegaly; abnormal liver function; -ve antinuclear antibody and RA factors. Blood test: WBC ↑, RBC ↓, ESR ↑ Treatment: anti-inflammatory drug → aspirin or NSAIDS steroids like prednisone, it persists 2nd line therapy: hydroxychloroquine, penicillamine, azathioprine and cyclophosphamide.