University:
Swansea University
Course:
PM-139 | Human Physiology 1
Academic year:

2023
Views:

111

Pages:

2
Author:

Amal J.

5) Muscle biopsy 6) CT/MRI 7) thyroid function test 8) chest X-Ray 1. Edrophonium 10mg of endrophonium is taken. Initially 2mg is injected into the weakened muscle area. After 1/2 a hour the muscle activity is come to normal → pt with M. Gravis 2. Testing of Antibody against ACE in serum-serological/ Ab test Differential Diagnosis → mitochondrial myopathy → periodical muscle paralysis → Eaten-Lambert syndrome / Lambert-Eaten/ myasthenic syndrome It's a presynaptic membrane disease → thyrotoxicosis → exophthalmus ophthalmoplegia → associated with sarcoidosis & lymphoma → polymyositis 1. Anticholinesterase drugs : → edrophonium intravenous → neosignine - oral/intravenous → pyridostigmine - oral more effective (Effect on 4-8 hrs) 2. Steroids → prednisolone 3. Immunosuppressants → azathioprine → cyclophosphamide → cyclosporine 4. Thymectomy 5. Plasmaparesis 6. Intravenous immunoglobulin