University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2023
Views:

246

Pages:

1
Author:

Carisma

Forg Haget Body adapts HOMEOSTASIS exist systems environmental to to understanding - changes : keep be able to PERSPECTIVE CELLULAR E MOLECULAR parameters in limits. healthy body habitually if And exceeds these limits, a state of disease resulti· Pharmacy attempts disease to correct using drugs homeostasis mechanisms with interact drugs of how physiological : · poumanismwhimessagearrivefrom where ↑ ON CHANNES enzymes : ligand binding things makes : allowing opens channel or breaks them enter/exit of ligand binding results in cell event De proteins is wall me a a containing all are proteins either ligands/substrates osynthetic drug ions : to site for binding drug target down DRUGS : Are not POTENCY · a < binds to target protein by stopping a being drug bound VERSUS drugs which stop drugs which SELECTIVITY to restore homeostasis Caveats-some drugs do not fit this models We do not know how they target have 1250 off-target (1Cso) - concentration of channels a receptors work stronger s, binding effects will present If a drug stops this ; the enzyme can't process the substrate /the enzyme stops working = enzyme inhibitor drug needed to target activity reduce to 50% normal value Lower Iso = more potent drug: required low amounts of drug - agonists measured with Elso-agonists will bind against drugs effecti to targets other but targets other Ideal - healthy homeostasis restore = if it binds less potently with higher 150 = selective non-selective drug=highly potent & Selective : ACE blood pressure Ag Receptor enzyme Antigiotensinogen Angiotensin , ↑ vasoconstrictions - ((az] = RECEPTOR AGONISTS /ANTAGONISTS cells substrates are antagonists blockers - agonists effect of natural in TRANSPORT even when RECEPTORS: a INHIBITION Inhibiting bound : drugs ENZYME stay inhibitor naturally occuring ligands from drugs on-target Similar transport : & will large DG-negative energy - occuring ligands making naturally same target of concentration in terms ION CHANNELS to transporter stops measured nerve ligand/substrate binding natural : Drug lines If occuring naturally INHIBITORS release - 1 Angiotensin 11 - ATAR I ↑ [P] = PL * : : neurotransmitter molecules to convey signals to other cells - Turned off Signals by neurotransmitter back to nerve cell that release them requiring transporter. blocking = Reuptake inhibitor elong