Mood Stabilization - Edubirdie

University:
Western Sydney University
Course:
MEDI 7006 | Applied Clinical Sciences 2
Academic year:

2024
Views:

63

Pages:

2
Author:

Mariam A. A.

Lithium ↓ NMDA -> ↓ glutamine ↑ GABA -> through GABA-B-R upregulation ↑ serotonin release & synthesis Combos used when disease is severe or refractory Side effects of Lithium -> contraindicated in renal failure stomach ache C, narrow therapeutic index, should be individualized according to serum levels & clinical response nausea + vomit ↑ thirst light headedness/drowsiness confusion/blackouts eye issues e.g. blurry vision polyurea, * hypothyroidism * ↑ weight Valproic Acid ↓ Voltage gated Na+ channels Side Effects nausea + vomit diarrhea dry mouth swollen gums tremors Other Options for mood stabilization Lamotrigine -> anti-convulsant Quetiapine -> atypical antipsychotic -> obtain baseline ECG before commencing either of these Psychotherapy ↳ reduces need for pharmacology & ↓ relapse rate

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