Clonzapine | Western Sydney University - Edubirdie

University:
Western Sydney University
Course:
MEDI 7006 | Applied Clinical Sciences 2
Academic year:

2024
Views:

137

Pages:

1
Author:

Mariam A. A.

Clozapine Clozapine -> 2nd gen anti-psychotic -> ECG -> myocarditis -> CBC -> agranulocytosis -> constipation MOA -> D2 antagonism -> serotonin 2A 5HT2A -> adrenergic-R -> Cholinergic-R -> Histaminergic-R -> other dopaminergic & serotonergic R 97% bound to serum proteins ANTAGONISM Elimination -> 50% in urine -> almost completely metabolised before excretion -> 30% in feces 1/2 life -> for 75mg -> 8 hrs 1/2 life -> for 100mg -> 12 hrs Indications *Schizophrenia *Bipolar *Acute psychosis *TDO *OCD -> as a concomittant med ADRs *metabolic -> weight gain, hyperglycemia *Myocarditis *prolonged QT *Neuroleptic Malignant Syndrome *↓ seizure threshold *sedation *somnolence -> a state of drowsiness from which a patient can be easily aroused

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