University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

367

Pages:

1
Author:

Nesbyenvkk

Clostridium Botulinum (+) Features: 1. Spore-forming 2. Obligate anaerobe Transmission: 1. Improperly canned food (in adults) 2. Honey (in infants) Pathogenesis: 1. Adults: a. Toxin absorbed by gut b. Cleaves SNARE protein c. Leads to prevention of exocytosis of Ach in the synapse d. Leads to flaccid paralysis 2. Infants: a. Infants don’t have normal intestinal flora to outcompete any ingested botulinum spore like adults do b. Ingestion of honey leads to spore going into gut where the spore produces the toxin c. Leads to flaccid paralysis Diseases: 1. In adults: a. Flaccid paralysis i. Descending ii. Early symptoms include ptosis and diplopia 2. In Infants: a. Floppy Baby Syndrome i. More common than adult botulism