University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

29

Pages:

2
Author:

kundgetanufv

Strep Pneumoniae (+) (GROUB B STREP) Features: 1. 2. 3. 4. 5. 6. Encapsulated (polysaccharide capsule) Alpha hemolytic Optochin sensitive Bile soluble Lancet-shaped diplocci Sickle cell (asplenia) patients are more susceptible to Encapsulated bacterial infections such as S. pneumonia Pathogenesis: 1. Polysaccharide capsule a. Major virulence factor 2. IgA Protease a. Helps in invading mucosa b. Reduces host defenses Diseases: Diseases are given the mnemonic MOPS. S. pneumonia is #1 cause for all of these. MOPS Meningitis Otitis Media Pneumonia Sinusitis Pneumonia o Lobar pneumonia o Infiltrates lower lobes o Rust colored sputum  Treatment: 1. Macrolides (erythromycin) 2. Ceftriaxone Prevention: There are two vaccines available: 1. Adult Vaccine (PPV, pneumococcal polysaccharide vaccine) 2. Pediatric Vaccine (PCV, pneumococcal conjugate vaccine)    Adult Vaccine 23 of most common capsular serotypes Not conjugated with protein T-cell independent response due to no protein conjugation    Pediatric Vaccine 13 of most common serotypes Conjugated with protein T-cell response due to protein conjugation  IgM produced  IgG produced