University:
Liberty University
Course:
BIOM 500 | Introduction to Biomedical Sciences
Academic year:

2024
Views:

462

Pages:

6
Author:

Sheha A.

Plasma Proteins Plasma: It is a liquid component of blood which has cells, platelets, and white blood cells. If the blood containing anticoagulant is centrifuged, the plasma separates as a supernatant while the cells collect at the bottom. Serum: It is the name applied to the liquid medium which separates out after blood clots. Serum does not contain clotting factors. Plasma Proteins: Albumin, globulins, and fibrinogen are three important classes of plasma proteins. The normal ranges of plasma proteins: Albumin: 3.5-5 g/dl Globulin: 2.5-3.5 g/dl Fibrinogen: 200-400 mg/dl Albumin It is the major plasma protein (60% of plasma proteins). It is synthesized in the liver. Globulin Globulin comprises the major fraction of total protein. It consists of many different proteins which are separated into 4 distinct bands in electrophoresis. 1. α1-Globulin: α1-antitrypsin, α1-acid glycoprotein 2. α2-Globulin: α2-macroglobulin, haptoglobin, ceruloplasmin 3. β-Globulin: Transferrin, β-lipoprotein, plasminogen 4. γ-Globulin: Immunoglobulins Fibrinogen Fibrinogen is a protein precursor. These are responsible for coagulation. Functions of plasma proteins Maintenance of colloidal osmotic pressure Transport of various substances Buffering action Immunity Albumin Albumin is responsible for the maintenance of plasma blood volume and body fluid distribution. This it will maintain the osmotic pressure of plasma. Transport Function Several plasma proteins serve as carriers of various compounds in the blood.