University:
Swansea University
Course:
PM-149 | Genetics, Genomics & Evolution
Academic year:

2023
Views:

236

Pages:

4
Author:

Amal J.

Chromosomal Abberrations Depending on parition Metacorbic cerhomere locale in middle Sub-Meta displaced toward one end large arm 2 small arm -p (pehte) 3 Accocentric - certvomece is near end one long small aim and one Telo cortic centromere al end Giemsa staining AT rich region - G-Band reveal ak Q-banda (Quinacein mustard) reveal GC rich res region C-bandt reveal centromeric helachromatic R-band (Reverse) - reveal ac rich region. Different type of Abbenahore :- Duplicatione @Tandem duplications ABCDEFGHIJ ABC D E F EFGHIJ ⑥ Displaced duplicchin ABCDEFGH EFIJ C Revere duplication ABCD EFFE GHIJ Deletion ABCD GHIJ Result of duplication and delection i looping aut of homologaw portions of ON feluring recombination? duplicated shand loop out in duplication - is delection normal strand loop aut Invesion →Pericentric include cerkvomere ABCD FEGHIJ Paracertic-do- not include Cenhomele ABCDEFGHIJ AGFE DOGHIJ Paicentric invenon ABCDHGEBIJ Paracentric inverin Effects of Dotation Duplication Duplication, hisomy ek leads to dosage imbalance. Es. Eye-size in deusophila Reason:- of duplication Unequal cheossing over. ⇒ Effects of Delction 1 Dosage imbalance Pseudo-dominance A a do not express DELETED a express Haplo-insufficient 2 normal allele Normal →phenotype Some Genes must be fresert in 2 nos/ulbele for normal functions: Achanchoplasia, familial Hypocholen if only one is present it will lead to Haplo insufficient Ez Drosophila Notch delchon. Human Chromosome 4 Chimpanzee chromosome 4 pericentric inverion Effect of paracerkvic inversioon at recombination during meoisis (in geum cells). leade to gereeation of Acertric fragment Dicerbric Cheomosome is lust d →dicentric brige - can easig -Corean's Anaphase viable so% 50%. Non-viable Normal non-recombinet gamet

Chromosomal Abberations and its Classifications

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