1.DOSAGE Understanding Dosage The definition of dose (measure) of a drug is the amount of a drug that can be used or given to a patient, whether for use as an internal or external drug. FI General Provisions III edition lists 2 doses, namely: 1). Maximum dose (maximum) Valid for use once and daily. Delivery of medicines in doses exceeding the maximum dose can be done by adding an exclamation mark and the initials of the doctor writing the prescription, placing a line under the name of the medicine or the amount of medicine should be written in full letters. 2). Usual Dosage are non-binding instructions but are used as general guidelines (usual/commonly used doses) 3) Various Doses Judging from the dose used, it can be divided as follows: 1) Therapeutic dose/Medicinal dose It is a dose (measure) that is given under normal circumstances and can cure the sick person. 2) Maximum dose This is the largest dose (measure) that can be given to adults for use once a day without harm. 3) Toxic dose Is the dose that causes poisoning, not death. 4) LD50 Is the dose (measure) that causes death in 50% of experimental animals. 5) LD100 Is the dose (measure) that causes death in 100% of experimental animals. 6) Initiation dose/Initial dos Is the dose (measure) given at the beginning of a therapy until the desired therapeutic level of action is achieved. 7) Maintenance dose This is the dose (measure) that must be given after reaching saturation to maintain the work and concentration of elderly tissue, so giving a smaller dose than the adult dose.The maximum dosage list according to FI is used for adults aged 20 - 60 years, with a body weight of 58- 60 kg. For people who are elderly and whose physical growth has begun to decline, the dose given is smaller than the adult dose -Dosage for pregnant women Pregnant women who are sensitive to drugs should be given in smaller amounts, even some drugs that can cause abortion are prohibited, as well as breastfeeding women, because the drug can be absorbed by the baby through breast milk. For children under 20 years old there are special calculations. -Dosage for children and infants The body's response to drugs in children and babies cannot be the same as that of adults. Choosing and determining the dose is not easy because several factors must be taken into account, including age, body weight, gender, nature of the disease, drug absorption capacity, drug excretion. Other factors include the patient's condition, the case of the disease, the type of medication, as well as tolerance, habituation, addiction and sensitivity factors. -Combined maximum dose If the prescription contains more than one type of drug that works simultaneously/in the same direction, then the combined maximum dose must be made. The combined maximum dose is stated not to be past if:1 time use of substance A + 1 time use of substance B, the results are less than 100%, as well as 1 day use.Examples of drugs that have combined DM: Atropine Sulfas with Extractum Belladonnae, Pulvis Opii with Pulvis Doveri, Coffein with Aminophyllin, Arsen Trioxide with Natrii Arsenas and others. -The dosage for the solution contains large amounts of syrup It must be noted that in drinking medicines that contain large amounts of syrup, namely more than 16.67% or more than 1/6, the BJ of the solution will change from 1 to 1.3, so the weight of the solution will not be the same as the volume of the solutio