1. What considerations do pharmacists need before making medicinal products? Give a brief explanation. 2. Why does solubility have a big influence on drug efficacy? 3. How do you maintain the stability of a medicinal preparation? 4. Explain the methods used to increase the solubility of a substance. 5. Why does the method of administering the drug affect the efficacy of the drug? 6. Mention the advantages of liquid dosage forms. 7. What is meant by the sieve method of mixing ingredients? 8. Cough syrup will be made with the active substance Dextromethorphan. Provide several alternative dosage forms that are suitable for children. 9. What is the function∝ − ℎ in emulsion preparations? 10. What additional ingredients are needed to make cream preparations? Answer 1. Assess the characteristics/properties of the medicinal ingredients and additional medicinal ingredients to be formulated, how to mix them and the influence of the dosage form on the expected efficacy. 2. Medicinal ingredients that are easily soluble in water will be more easily absorbed so they will provide a therapeutic effect more quickly. So for active substances that are easily soluble and stable in water, it is better if they are made in liquid form 3. To maintain the stability of drug preparations, the following are: *addition of certain additional ingredients (for example: preservatives). *proper packaging. *providing instructions on correct storage methods. 4.*micronization (reducing the particle size of a substance so that it dissolves easily). *form complex compounds that are soluble in water (for example in the formation of NaI complex compounds3, K.I3). *use the salt form (for example: Phenobarbital in waterdifficult to dissolve , replaced by the salt form, namelyPhenobarbital Na which is easily soluble in water). using mixed solvents (eg water and ethanol such asin Elixir preparations. 5. The method of administering the drug will affect the rate of absorption of the active substance. 6. - Absorption/absorption of drugs is faster than solid dosage forms. - Dosage uniformity is more guaranteed than in solid dosage forms because in solution form the drug ingredients are molecularly dispersed. - If it is to be diluted or mixed with other medicinal ingredients, ensure uniformitymedication remains intact. - Preferred by sufferers who cannot swallow tablets or capsules. - Can be given attractive flavorings or colorings so that it can increase compliance with taking medication in sufferers, especially children 7 The ingredients are mixed by passing them through a sieve 8 The preparations that can be chosen are syrup or elixir. 9 Antioxidant. 10 Cream base, fragrance, preservative and coloring.