MODULE 11 PHARMACY TECHNOLOGY PRACTICUM SOLIDA PREPARATIONSMANUFACTURING OVULA STOPS OBJECTIVE Students can find out how the process of making Ovules is carried out. COMPLETE FORMULA R/ Metronidazole 500 mg Lactic acid 84 mg PEG 1000 906 mg PEG 4000 2,719 mg The number of ovules produced is 10 ovules WEIGHING 1. Do a review study of the formula above. 2. Weighing is carried out to produce 10 ovules. PROCESSING 1. Weigh all the ingredients needed 2. The ovule mold is prepared, the mold must be clean and dry. 3. Spread lubricant (paraffin liquid) into the mold, then turn the mold upside down so that there is no buildup of glycerin in the mold. 4. The PEG mixture is melted while stirring until homogeneous. 5. Heat-resistant active substances can be stirred with melted PEG in a water bath. 6. Put the melt into the mold. 7. The melt is allowed to solidify at room temperature, ± 15 minutes. 8. Put it in the refrigerator for 10 minutes, then put it in the freezer for 5 minutes. 9. After solidifying, the excess mass is cut off, then the ovules are removed from the mold. 10. Evaluate the ovules in the next practicum. MODULE 12 PHARMACY TECHNOLOGY PRACTICUM SOLIDA PREPARATIONSEVALUATION OF SUPPOSITORIES & OVULES Medicinal products or raw materials, excipients included in the scope of the Pharmacopoeia must meet the requirements in the Pharmacopoeia. For this reason, it is necessary to evaluate the suppository and ovule preparations. TOOLS AND MATERIALS 1. The finished suppo/ovule will be tested 2. Vernier caliper 3. Analytical scales 4. Cuter 5. Time disintegration test equipment TESTING PROCEDURE 1. Appearance This test is more attached to the distribution of nutritious substances in the suppo base and ovules. Suppo.The ovule is split longitudinally and then observed, the internal part and the external part must be shows uniform visualization. 2. Uniformity of Content The test is carried out to determine the levels of active substances in each suppo/ovule, the concentration determination is carried out on the suppo/ovule. The levels of active substances in suppo should not be outside the requirements set out in the FI monograph and the variations should not be large. 3. Diversity of Weights Weigh 20 suppos/ovules each, take them at random. Determine the average weight, there should be no more than 2 supp whose weight deviates from the average weight (SD ± 5%). 4. Time Crush Test This test is carried out on the suppo/ovule. Tests were carried out on 3 suppos/ovules.mThe suppo/ovule is inserted into a cylindrical metal container whose end is closed.mThe pacadang is then inserted into a moving cylindrical glass. Except stated otherwise, each suppo/ovule dissolves at a temperature between 36-37oC. the time required to crush the suppo/ovule for no more than 30 minutes for the fat base and no more than 60 minutes for water soluble bases. 5. Hardness/Toughness Test The toughness test is the resistance of the suppo/ovule to the point that it does not break when given quantity the greater the load, this test is intended to maintain the dosage form intact until used. The suppo/ovule to be tested is placed in the test apparatus in a standing position, with a load then added. Adding weight starts with a weight of 600 g then increases by 200 g every minute and done until the suppo/ovule ruptures. The weight of the load added up toruptured suppo/ovule is the hardness value.