MODULE 8: PRACTICUM ON PHARMACEUTICAL TECHNOLOGY SOLIDA PREPARATIONS TABLET EVALUATION: PHYSICAL EVALUATION Medicinal products or raw materials, excipients included in the scope of the Pharmacopoeia must meet the requirements in the Pharmacopoeia. For this reason, tests are needed on the granules before the printing process is carried out. TOOLS AND MATERIALS 1. Finished tablet to be tested 2. Vernier caliper 3. Analytical scales 4. Hardness tester 5. Fria/frixi tester TESTING PROCEDURE 1. Organoleptic Observation of shape, smell, color and taste is carried out visually. 2. Tablet Uniformity a.Size Uniformity The tablets tested were 20 tablets. Measure the diameter and thickness of each tablet withVernier calipers. Draw conclusions from the tested tablets. b.Weight Uniformity The tablets tested were 20 tablets. Weigh each tablet with an analytical balance.Draw conclusions from the tested tablets.Table of weight uniformity requirements according to the Indonesian Pharmacopoeia IV edition Average weight deviation in % Average weight A B 25 mg or less 15 30 26 mg to 150 mg 10 20 151 mg to 300 mg 7.5 15 More than 300 mg 5 10 If weighed one by one, there should be no more than 2 tablets whose respective weights deviate from the average weight by more than the price set in column A, and not a single tablet whose weight deviates from the average weight by more than the price set in column B. 3. Tablet Hardness Hardness is a parameter that describes the tablet's resistance to mechanical stress such as shock, abrasion and cracking of the tablet during packaging, transportation and use. The tools used arehardness tester. Hardness test of 20 tablets. 4. Friability and Frixibility a.Friability (brittleness) Fragility is a parameter used to measure resilience the surface of the tablet against the friction it experiences during packaging and delivery.The principle is to determine the weight lost by a number of tablets during rotation in the friabilator for a certain time. In the process of measuring fragility, the tool is rotated with a speed of 25 revolutions per minute and the time used is 4 minutes. Sothere are 100 rounds. Test the friability of 20 tablets using the Friabilator. b.Frixibility Frixibility is a parameter used to measure resilience the surface of the tablet against friction between tablets that it experiences during the process manufacturing and packaging. The principle is to determine the weight lost by a number of tablets during rotationin the frixibilator for a certain time. In the process of measuring frixibility, tools rotated at a speed of 25 revolutions per minute and the time used is 4 minute. So there are 100 rounds.Frixibility test of 20 tablets using Fixibilator. DISCUSSION AND CONCLUSIONS Discuss the results of testing the granules and what conclusions can be drawn from these tests.