Module 1: INTRODUCTION TO TOOLS I. PURPOSE To prepare tools and materials for making solid preparations II. SCOPE This is carried out on the tools and materials that will be used in making solid preparations. III. SPECIAL ATTENTION The introduction is carried out in the pharmaceutical technology laboratory IV. EQUIPMENT A. Tablet printing equipment a. Scales b. Mixing tool c. Mesh filter d. Drying cabinet/oven e. Tablet printing machine f. Punches and dies B. Tablet test equipment - Friability/frixibility tools - Dissolution tool - Time tool is destroyed - Tablet hardness testing tool V. PREPARATION FOR TESTING 1. Pay attention to all the tools that will be used in the solida practicum. 2. Pay attention to how to install the tool, instructions on how to operate it and instructions on how to clean the tool so that the tool is durable and can be used many times. MODULE 2: PRACTICUM ON PHARMACEUTICAL TECHNOLOGY SOLIDA PREPARATIONS PREFORMULATION AND MASTER FORMULA OF SOLIDA PREPARATIONS I. PURPOSE To know the formula and master formula and calculate ingredients in making solid preparations II. SCOPE Carry out calculations and weigh the ingredients needed to make solid preparations III. SPECIAL ATTENTION Calculations were carried out in the pharmaceutical technology laboratory IV. EQUIPMENT Tool a. Preparation formula b. paper c. stationery d. calculator e. analytical balance f. container for ingredients Material a. Active ingredients according to formula. b. Suitable additional ingredients V. PREPARATION FOR TESTING 1. Pay attention to how to carry out calculations according to the formula that will be created. 2. Pay attention to how to weigh the ingredients on the analytical balance. VI. COMPLETE FORMULA Given a formula to make 450mg tablets. It is planned to make 300 tablets. FORMULA 1 FORMULA 2 FORMULA 3 DEEP PHASE (92%) DEEP PHASE (92%) DEEP PHASE (92%) Paracetamol 250mg Mefenamic Acid 250mg Mefenamic acid 250mg Amprotab (10%) Amprotab (10%) Amprotab (10%) Amylated mucilage(15%) PVP (10%) Avicel ph 102 (10%) Lactose qs Lactose qs Lactose qs OUTER PHASE (8%) OUTER PHASE (8%) OUTER PHASE (8%) Mg stearate (1%) Mg stearate (1%) Mg stearate (1%) Talk (2%) Talk (2%) Talk (2%) Amprotab (5%) Amprotab (5%) Amprotab (5%) VII. CALCULATION Number of tablets to be printed is 300 tablets. Weight per tablet is 450 mg Total weight to be made 300 x 450 = 135000 mg = 135 g Phase in 92% = 135 x 0.92 = 124.2 g Formula 1 Paracetamol 250 mg x 300 = 75000 mg = 75 g. Amprotab 10% of the inner phase Mucilago = 124.5 g x 0.1 = 12.45 g amil 33% of the inner phase Total of the 3 = 124.2 x 0.15 = 18.63 g ingredients above = 75+ 12.45 + 18.63 = 106.08 g So Lactose is added = 124.5 – 106.08 = 18.12 Final granule after drying 116.75 g. This is 92% of the Tablet's weight. Shrinkage 116.75/124.2 x 100 % Mg stearate 1% 116.75 x 100/92 x 1% Starch 5% 116.75 x 100/92 x 5% Talk 2% 116.75 x 100/92 x 2% VIII.WEIGHING 1. Do a study of the formula above. 2. Weighing is carried out to make 300 tablets.