TESTING THE EFFECTS OF STIMULANT DRUG Practical Objectives Students can recognize, study and practice the effects of stimulant drugstonic preparations on the market with methodsNatatory Exhaustion. Basic theory. A stimulant is a substance that can stimulate the central nervous systemspeed up processes in the body, can increase physical and mental abilities,increases concentration, can make you more alert and can minimize fatigue.Caffeine is widely consumed and is used as a stimulant for the central nervous systemman. Tonics or tonic substances are drinks or medicines that can have an effect strengthens and increases appetite. The tonic effect is called the tonic effect, namely stimulating and Strengthens all systems and organs and stimulates repair of muscle tone cells. Tonic effect occurs due to stimulants exerted on the central nervous system. The tonic effect is classified into the group of psychostimulants, compounds that can increase psychic activity, Eliminates fatigue, stress and increases the ability to concentrate and the capacity concerned. The resulting stimulants act on the cortex causing Fatigue-resistant effect, mild stimulation. The tonic effect can be determined using the methodnatatory exhaustionthrough observing the stimulant effect of a drug on test animals.. Tools and materials Tool a. Swimming tub (glass/plastic box filled with water), ritarod (rotating rod) b. Stopwatch c. 1 mL oral injection syringe d.hairdryer e. towel f. glassware g. syringe h. Gloves Material:Caffeine Test Animals:Mice Work procedures 1. Group Categorizer Group 1 was administered caffeine at a conversion dose from humans group 2 was administered a tonic product (Situmuno) dose conversion from use on man Group 3 was administered distilled water 2. Test the effects of stimulants a. Before administering the drug, the mice were put into a glass box contains water. The mice were swam until they showed a tired condition, that is, there was no reaction meaningful movement of the four legs, body position bent, tail stretched and let the head be below the water surface for 4-7 seconds. Then the fatigue time was recorded two seconds after putting the mouse in the boxglass until the mice appear tired, the time recorded as the first tired time (tired time before treatment). b. The mice were rested for 30 minutes, wiped with a towel and given air warm withhair dryer. c. Then the mice were given the test solution randomly according to the group division above and left again for 10 minutes as an estimate of the pharmacokinetic period test preparation in the body of mice d. The mice were swam again until a tired reaction appeared as was the initial observation, recorded as the fatigue time and the time recorded as the second fatigue time (tired time after treatment) The stimulant effect data is the difference in fatigue time, namely the second fatigue time (tired time after treatment) minus the first fatigue time (tired time before treatment)