HOW TO GIVE MEDICINE TO ANIMALS 1. Mice a. Orally:Fluidusing an oral probe. Oral soundattached to the roof of the mouthmice, then slowly inserted into the esophagus and fluid medication is administered. drug given with b. Sub Cutaneous The skin in the nape area is lifted and medicine is inserted into the lower part of the skin using a 1 ml syringe & a 27G/ 0.4 mm needle. Apart from that, it can also be in the back area of mice. c. Intravenous Mice were placed in mouse restriction cages, with their tails sticking out. The tail is dipped in warm water (28-30 ºC) so that the tail vein dilates, making it easier to administer medication into the vein. Drug administration is carried out using syringe no. 24. d. Intramuscular The drug is injected into the posterior thigh with syringe no. 24. e. Intraperitoneal At the time of injection, the head position is lower than the abdomen. The needle is injected at an angle of about 100 from the abdomen in an area slightly away from the midline, so that the syringe does not hit the bladder. The injection is not in an area that is too high to avoid injecting the liver. Rats a. Givingorally, intramuscularly, intraperitoneally and intravenouslythe same way as in mice. b.Subcutaneous administration is carried out on the skin of the nape of the neck or the skin of the abdomen. 3. Rabbit a. Orally: Oral administration of medication to rabbits is carried out using a jaw restraint and feeding tube number 6-8. b. Subcutaneous: Subcutaneous administration of medication is carried out on the side of the waist or nape of the neck by lifting the skinThe needle (25-26 g) is inserted anteriorly. With a maximum administration volume of 1% BW. c. Intravenous: Injectionmarginalis in the area near the tip of the ear. Before injection, the ear is moistened first with alcohol or warm water d. Intramuscular Giving performed on the hamstrings. Avoid the posterior muscles of the femur due to the risk of sciatic nerve damage. Use a 25ga needle and an administration volume of no more than 0.5-1.0 ml/injection site.intramuscular can e. Intraperitoneal Position so that the head is lower than the stomach. The injection is made in the midline at the front of the bladder.