Pharmaceutical Calculations Examination

STUDENT NUMBER Faculty of Science and Engineering School of Pharmacy Examination Paper EXAM DETAILS Module Code Module Title Date of Exam Duration (incl. reading time) Module Leader / Examiner 4PY019 Pharmaceutical Calculations Examination Semester 2-May 2024 1 hour Module lead: Matthew Palframan Examiner: Gurpreet Sahota/Zeeneh Elsaid INSTRUCTIONS FOR STUDENTS This is a closed book examination, which consists of 20 ‘fill in the box’ questions to be completed in 1 hour. Print your student number clearly in the space provided at the bottom of this page. Attempt ALL questions. The pass mark is determined by cut-scoring and there is no negative marking. Write your final answer in the ‘Answer’ section at the bottom of each question, using the pre-printed answer grid. Your final answer must be written in the answer grid using a pencil. If you wish to change an answer, rub out your first solution carefully, taking care not to smudge across the boxes, then re-write your answer clearly. The decimal point is already placed on the answer grid. When completing the answer grid use the pre-entered decimal point to guide you. For example, if the answer is 118 tablets, fill in the answer as shown below. For whole numbers, do not enter zeros after the decimal point. Decimal points are provided. If the answer contains a decimal point, use the decimal point that is pre-entered. For example, if the answer to a question is 450.5 g, fill in the answer as shown below. Do not use commas. For example, if the answer is four hundred and thirty thousand units, write this as 430 000 as shown below. However, if the answer is less than 1, then enter a ‘leading’ zero, e.g. write 0.15 mL as shown below It is an examination requirement that you show a logical working out process to arrive at a computed answer. Accordingly, even where a submitted answer is correct, it will not be awarded a mark in the absence of a logical working out method with supporting numerical data. 1 Read the questions carefully, and ensure that all answers are expressed in the units specified in the answer box EXAM INFORMATION – PLEASE READ • DO NOT OPEN THIS PAPER UNTIL YOU ARE INSTRUCTED TO DO SO BY THE INVIGILATOR. • All electronic devices must be SWITCHED OFF and placed with your belongings (incl. mobiles and wearable technology). • You must not have any unauthorised materials on your person or on your desk. • Place your ID on your desk. • You will not be allowed to leave the exam room within the first hour, or the final 30 minutes. • Raise your hand if you need to get the attention of an Invigilator. • This paper MUST NOT be removed from the exam room. 2 Question 1 Express 840,000 micrograms in grams. Give your answer to two decimal places. Answer g Question 2 Express 560 (litres) in millilitres. Answer mL Question 3 How many milligrams of potassium permanganate are required to prepare 10 L of a 1 in 5,000 solution? Answer mg 3 Question 4 An antibiotic dose is given to a child at a dose of 250 micrograms/kg every 8 hours. The child weighs 8kg. How many milligrams of the antibiotic will the child have received after a 5-day course of treatment? Answer mg Question 5 A bottle of eye drops contains drug H at a concentration of 0.3 %w/v. It is available in bottles containing 5ml. How many milligrams of drug H does each bottle contain? Answer mg 4 Question 6 An injection is available as a 1 in 2000 solution. An adult is given 4mg. How many millilitres of the injection will contain the dose administered? Answer mL Question 7 A patient weighing 60kg requires drug J at a total daily dosage of 20mg/kg given in two divided doses. Drug J is available as 150mg tablets. How many tablet(s) will provide one dose? Answer tablet(s) Question 8 You receive a prescription for a 4-year-old child for a chest infection. The dose is 125mg to be given four times a day for a total of 7 days. The medicine is available as an oral liquid containing 70mg/ml. How many millilitres of the oral liquid would you need to dispense to complete the prescription? Answer mL 5 Question 9 Drug L is available as a 1 in 50 solution. If the relative molecular mass is 200, what is the molar concentration of [M] (expressed in moles/litre) of this solution. Give your answer to one decimal place. Answer M (moles/L) Question 10 Drug R is available as capsules each containing 25 micrograms of the active pharmaceutical ingredient. A patient is prescribed 0.1mg of drug R, as a once daily dose. How many capsule(s) of drug R should be dispensed for 28 days’ treatment? Answer capsule(s) 6 Question 11 What is the resulting concentration (expressed as %w/v) of a glucose solution be, if 100 ml of 30 %w/v glucose is mixed with 100ml of 20 %w/v glucose? Answer % w/v Question 12 A stock solution of disinfectant is available as 6 %w/v, which is diluted before use. How many millilitres of water are required to prepare 15L (litre) of a 1 in 5000 solution of the disinfectant? Answer mL 7 Question 13 A patient has been started on a new medication while in hospital. The starting dose is 200mg three times a day for one week, followed by 200mg twice a day for two weeks and then the patient will continue on a dose of 200mg once a day for a further week. The tablets are available as 200mg. How many tablet(s) should be dispensed for the first 4 weeks of treatment? Answer tablet(s) Question 14 How many milligrams of active pharmaceutical ingredient (API) are required to produce 5kg of cream containing 20 %w/w API? Answer mg 8 Question 15 How many millimoles of sodium bicarbonate (NaHCO3) are present in a 20ml ampoule containing 8.4 %w/v ?[ Ar Na = 23, H = 1, C= 12, O=16] Answer mmol Question 16 A doctor orders 150g of an ointment containing 0.5 %w/w active pharmaceutical ingredient which can be prepared by diluting an ointment containing 3 %w/w API with a suitable diluent. How many grams of the 3 %w/w ointment would be needed to prepare the product the doctor ordered? Answer g 9 Question 17 You are preparing sodium chloride eye drops by dissolving 400mg of sodium bicarbonate in water, which you make up to final volume of 5ml. What is the concentration (expressed as %w/v) of the resulting solution? Answer %w/v Question 18 Drug G (which can be diluted with water) is available as 50 %w/v stock solution. A prescription is received for 160ml of a solution of drug G containing 250mg/5ml. How many millilitres of the stock solution should you dilute to prepare this prescription? Answer mL 10 Question 19 A drug is prescribed at a dose of 30mg/kg/day given in divided doses. On admission to hospital, Mr P is taking three 200mg capsules every 6 hours. If the dose is correct, what is Mr P’s weight in kilograms? Answer kg Question 20 A patient is prescribed ‘Hear clear’ ear drops with directions to use 2 drops in both ears every eight hours for 10 days, then reducing to 2 drops in each ear twice a day for 10 days and then stop. 1ml of the ear drop solution produces 20 drops. A bottle contains 5ml of solution. How many bottle(s) are required for this course of treatment? Answer bottle(s) 11