University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

302

Pages:

19
Author:

Carisma W.

FACULTY OF SCIENCE & ENGINEERING SCHOOL OF PHARMACY EXAMINATION PAPER Module Code 4PY019 Module Title : Introduction to Drugs and Medicines Date May 2022 Examiners : Drs Zeeneh Elsaid, Mark Hewitt, Waseem Kaialy, Mathew Palframan and Ben Butler Time Allowed : 2 Hours INSTRUCTIONS TO CANDIDATES Answer ALL sections. Section A (25%): Answer all 20 multiple choice questions on the answer grid provided on the last page of the question paper. All questions have ONLY ONE correct answer. If none or multiple answers are circled, marks will not be awarded. There is no negative marking • Sections B: B1-3 (75%) Answer all short answer questions. Answer each question in the spaces provided. MATERIALS REQUIRED You may use a scientific calculator. This must not be programmable. Periodic Table (located at the end of the examination paper) Student Number: SECTION A: Answer ALL 20 questions on the answer grid provided at the end of the exam paper. Each question is worth 1 mark. 1. You prepared a solution of a weak monoprotic acid by dissolving 0.080 moles of the acid in enough water to make 1.0 litre of solution. The pH of the resulting solution was 4.51. What is the value of K_{a} for this acid? A 9.5 * 10 ^ - 10 B 3.9 * 10 ^ - 4 C 1.2 * 10 ^ - 8 D 1.8 * 10 ^ - 5 E 6.1 * 10 ^ 1 2. In relation to acids and bases, which of the following statements is FALSE? A An acid is a substance that contains hydrogen and dissociates in water to yield a hydronium ion B An acid is a substance that will donate a proton C A base is a substance that contains the hydroxyl group and dissociates in water to yield OH- D A base is a substance that will accept a proton E An acid is an electron-pair donor 3. In relation to excipients used in compressed tablets, which of the following statements is INCORRECT? A B An example of a colouring agent is lactose C An example of a binder is starch D An example of a lubricant is talc E An example of an anti-adherent is magnesium stearate An example of a glidant is colloidal silica B1) e) Explain why you think it is important to publish clinical trial data. (2 marks) B2) a) You are a team member working on a drug development project in a large pharmaceutical company. The compound below (Isostat) is being investigated for use in the treatment of angina. N N The compound has received a positive Ames test result (with liver fraction). Describe what the Ames test is and what a positive result indicates. (5 marks) 11