University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

65

Pages:

2
Author:

Sara

1. Medicinal Chem- Designing effective drugs by considering protein interacistry tion and site of action 2. ADME Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion of drugs 3. Lipinski's Rule of Guideline for drug likeness based on physicochemical Five properties 4. Molecular Weight Mass of a molecule 5. Log P Partition coefficient indicating lipophilicity 6. Octanol in log P Method to determine partition coefficient using octanol Determination 7. The Effect of pH Influence of pH on distribution of a molecule on Partitioning 8. Solubility Ability of a substance to dissolve in a solvent 9. Altering Solubili- Changing the ability of a substance to dissolve ty 10. Predicting solu- Estimating the ability of a substance to dissolve bility 11. Lipinski's Rule of Criteria for drug-likeness based on molecular weight, Log Five P, H-bond donors, and H-bond acceptors 12. Molecular Weight Molecules should be less than 500 to enhance oral abRule sorption, except for natural products like Erythromycin 13. Octanol Non-polar solvent used in log P determinations, mimicking a cell membrane's hydrophobic tail 14. Effect of pH on Partitioning pH influences a compound's solubility in polar and non-polar solvents, impacting absorption 15. 1/2 Weakly Acidic Drugs 16. Weakly Basic Drugs Unionized in gastric fluid, ionized in intestinal fluid, affecting absorption locations Protonated in gastric fluid, de-protonated in intestinal fluid, influencing absorption sites 17. Aqueous Solubil- Essential for drug absorption; affected by various factors ity like temperature, pressure, and molecular properties 18. Dissolution Change from solid to liquid state requiring energy; influenced by heat to break solid bonds 19. Pressure Effect on Solubility Increasing pressure affects gas solubility, leading to supersaturated solutions 20. Melting Point vs. Compounds with high melting points often have poor waSolubility ter solubility 21. Molecular Shape Symmetrical molecules pack tightly with stronger forces, Impact affecting melting point and solubility 22. Molecular Weight Higher weight correlates with decreased water solubility Influence due to increased hydrophobic nature 23. Hydrogen Bond- Ability to form hydrogen bonds affects solubility; too strong ing bonds can reduce water intervention 24. Polar Functional Ionisable groups like acids and bases increase water solGroups ubility 25. Functional Group Substitution Altering compound solubility by replacing functional groups; used in lead development for drug candidates 26. Computational Prediction Tools predict solubility by analyzing structural features' contributions 27. Drug Discovery Criteria Molecule must bind to target, be absorbable, stable in stomach, survive metabolism, have low toxicity, and be synthesizable 2/2