University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

280

Pages:

3
Author:

Sara

parietal goblet/mucous neck cell ECL G cell D cell chief cell name the 6 cells of the stomach what do mucous neck cells secrete? function? HCO3- and mucous -neutralise acid at stomach lining, preventing damage what do parietal cells secrete? function? HCl -pepsinogen > pepsin Fe3+ > Fe2+ intrinsic factor -absorption of vit.B12 what do ECL cells secrete? function? histamine -stimulates acid secretion what do G cells secrete? function? gastrin -stimulates acid secretion + ECL cells what do D cells secrete? somatostatin -inhibits acid what do chief cells secrete? pepsinogen what does a high acid environment in oesophagus result in? Barrets Oesophagus what does a high acid environment in SI result in? duodenal ulcers what forms of cell signalling does parietal cell receive? endocrine neurocrine paracrine cephalic, gastric, intestinal 1/3 what are the 3 phases of acid secretion? how does a parietal cell secrete acid? what classes of drug treat PUD? 1. H2 receptor antagonists -idines e.g. ranitidine 2. PPIs -prazoles e.g. lansoprazole, omeprazole what is H.pylori? bacteria that can lead to gastric cancer what type of organ is the pancreas? retroperitoneal (behind the peritoneum) what are the functions of pancreas? exocrine > secretion of pancreatic juice into bloodstream endocrine > secretion of hormones into bloodstream 90% of pancreatic function loss and sehow do we define pancreatic insufficiencretion of enzymes [by acinar cells] is cy? less than 10% what 2 cells are responsible for exocrine pancreatic secretions? acinar cells duct cells what hormone stimulates acinar cells? CCK what hormone stimulates duct cells? secretin compare composition of ductal fluid when there is high flow rate vs when there is a low flow rate: where does ductal modification take place? in lower duct cells, due to stimulation by secretin secretin stimulates opening of CFTR channel 2/3 how are HCO3-/Cl- produced by acinar + upper duct cells? how are pancreatic secretions controlled? small I - brush border enzyme enterokinase activates trypsinogen > trypsin How are pancreatic enzymes activated? trypsin > activates zymogens summary of 3 main digestive hormones? summary of stomach + pancreas actions: 3/3