Drug Toxicity II Lecture | University of Wolverhampton - Edubirdie

University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

69

Pages:

2
Author:

Sara

1. Drug Toxicity Adverse effects of drugs on the body 2. Manifestations of Toxicity Symptoms or signs of drug-induced harm 3. Molecular Mechanisms of Processes at a cellular level causing harm Toxicity 4. Drug Metabolites Chemical products of drug metabolism 5. LD50 Lethal dose killing 50% of treated animals 6. Therapeutic Index Ratio of toxic to therapeutic drug dose 7. Animal Testing Benefits Assessing drug safety and efficacy 8. Animal Testing Limitations Differences in species responses 9. Genotoxic Potential Ability of a substance to damage genetic information 10. Ames Test In vitro test for mutagenicity using Salmonella bacteria 11. Cytogenetic Evaluation Assessing chromosome damage in response to a drug 12. Carcinogenicity Testing Testing for cancer-causing potential 13. Reproductive Testing Assessing drug effects on pregnancy and birth defects 14. NOAEL Highest dose without adverse effects 15. HED Human Equivalent Dose based on animal studies 16. Therapeutic Index Impor- Measure of drug safety based on LD50 and tance ED50 17. Theophylline Monitoring 1/2 Narrow therapeutic index drug requiring serum level checks 18. Elixir Sulfanilamide Disas- Mass poisoning leading to drug safety regulater tions 19. TGN1412 Trial Toxicity trial highlighting flaws in drug testing 20. Cytokine Storm Overactive immune response causing harm 21. Biological Knowledge Gap Lack of understanding of biological processes 22. Blister Test Skin exposure test to check for adverse reactions 23. Prevention of Toxicity Avoiding harm based on toxin mechanisms 24. Mutagenic Potential Ability to cause genetic mutations 25. Teratogenic Potential Ability to cause birth defects 2/2

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