Exam Questions Revision Sessions - Edubirdie

University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

498

Pages:

1
Author:

Sara

1. Explain why the partition coefficient is a critical physiochemical property: (5) - it helps us understand how a drug crosses a membrane + its distribution - ADME profile - it controls how much the drug can be distributed around the body - log P is used as a predictor of a drug's bioavailability, which is the fraction of an administered drug dose that reaches the systemic circulation + is available to exert its therapeutic effects - it also tells us how hydrophobic/hydrophilic a drug is 2. How do you increase a - add polarity to a molecule making it more water molecules water solu- soluble bility + why it do this? - decrease molecular weight making it smaller 3. What is the orange guide? rules + guidance for pharmaceutical manufacturers + distributors 4. A tablet of vitamin C contains 1000mg of ascorbic acid which has a pKa of 4.13. If a single vitamin C tablet is completely dissolved in 85mL of water, what is the pH of the final solution? pka = 4.13 ka = 10^-4.13 = 0.0000741 mass = 1000/1000 = 1g mr = 176.12 moles = 1/176.12 = 0.0056 85mL = 0.085L conc = moles/volume (5 marks) 0..0056/0.085 = 0.0668M H+ = Ka x absorbic acid square root of 0.0000741 x 0.0668 -log(H+) = 2.65 1/1

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