University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

37

Pages:

2
Author:

Sara

Live attenuated vaccines ADVANTAGES 1) The vaccine has an attenuated but alive microorganism, so the immune response is strong, more similar to natural infection. VERY EFFICIENT Cue: Regarding the immune response, is it similar or quite different to natural infection with the pathogen? 2) Live attenuated vaccines induce a strong response so few doses are required, in some cases they offer long-time immunity Cue: How many doses are needed? 3) Live attenuated vaccines induce a full immune response humoral and cellular Cue: What kind of immune response is induced? DISADVANTAGES 1) Severe reactions possible. The vaccine cannot be administered to immune compromised patients 2) The attenuated pathogen still replicate in our body. Many cycles of replication can introduce mutations that recreate the wildtype unattenuated pathogen and cause full disease. Cue: The attenuated pathogen is alive, so…can it replicate itself? What can this lead to? 3) Live attenuated vaccines are fragile – must be stored carefully in refrigerated conditions, etc Cue:About storage, Is the vaccine going to be easy to store? (cue: the vaccine has a microorganism that is alive)? Inactivated vaccines ADVANTAGES 1) The vaccine CAN BE administered to immune compromised patients 2) The inactivated vaccine has not got a pathogen that replicates in our body. So, there is no risk of recreating the wild-type unattenuated pathogen and cause full disease. Cue: The inactivated vaccine has not got a microorganism alive, so…can it replicate itself? What can this lead to? 3) Inactivated vaccines are easy to be stored Cue:About storage, Is the vaccine going to be easy to store? (cue: the vaccine has not got a microorganism that is alive)? DISADVANTAGES 1) The vaccine has not got an alive pathogen, so the immune response is not going to similar to natural infection. Immune response weaker than in live attenuated vaccines. NOT AS EFFECTIVE Cue: Regarding the immune response, is it similar or quite different to natural infection with the pathogen? 2) Inactivated vaccines induce a response that is not the strongest possible, so more doses are required. Cue: How many doses are needed? 3) Inactivated vaccines tend to induce only antibody-based response Cue: What kind of immune response is induced?