University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

296

Pages:

3
Author:

Sara

1. Which of the following statements describes a suspension? a solid dispersed in a liquid continuous phase 2. In relation to suspensions, in case of oral suspensions containing more which of the following than 1 API, some API may be in solution statements is CORRECT? 3. Which of these is NOT increased patient compliance an advantage of parenteral drug administration? 4. Which of the following statements about rectal drug delivery is CORRECT? - rectal delivery is often used to provide local effect - rectal drugs can be absorbed through the rectal mucosa to provide a systemic effect - enemas are divided into 2 forms, evacuant + retention 5. Which of the following statements about rectal drug delivery is INCORRECT? rectal dosage forms include suppositories + pessaries - as pessaries is vaginal dosage forms 6. A change in which factor osmotic pressure listed below will NOT affect log D? 7. In terms of the partition coefficient (P) / its logarithm (logP), which of the following statements is INCORRECT? - an octanol-water system is commonly used since octanol mimics phospholipids - logP provides an insight as to how a drug distributes within the body - drugs with high log P values can show poor bioavailability due to accumulation in biological membranes 8. Which of the following polar solvents have high dielectric constants statements is CORRECT? due to them containing electronegative atoms 1/3 9. Which of the following statements does EXPLAIN why water solubility is considered to be a critical physicochemical property? - a drugs water solubility will control its ability to cross biological membranes - poor water solubility can lead to poor bioavailability - poor water solubility can lead to problematic drug formulation 10. Which of the following statements does NOT explain why water solubility is considered to be a critical physicochemical property? a drug must hydrolyse + enter solution to be an effective drug - not true as not all drugs need to hydrolyse to be effective. 11. Which of the following op- can exceed the volume of water in the body tions correctly completes the following sentence? The apparent volume of distribution of drugs in humans ... 12. Acidic drugs... in an acidic environment are lipid soluble + readily pass across membranes 13. A patient who has a below have above average "steady state" value average value for clearance of a particular drug will... 14. Discuss the ethics of testing drugs in animals and indicate how ethics are maintained during this research: - inspections are made - it's also against the law for any researcher to cause unnecessary suffering to any animal - 3R's = replacement, refinement + reduction 15. What are the start and stop - start = AUG codons? - stop = UAA, UAG, UGA 16. Where does transcription nucleus occur? 2/3 17. Where does translation oc- ribosomes in the cytoplasm cur? 3/3