Acid and logP - Edubirdie

University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

349

Pages:

1
Author:

Sara

1. Compare the general characteristics of acids + bases. What is the difference between a strong acid + weak acid? - acids have a sour taste react with metals, contain hydrogen + many are poisonous + corrosive to skin - bases usually taste bitter, feel slippery + contain OH- ions - strong bases also poisonous + corrosive to skin - strong acids break down completely to give off many H+ ions. example HCl - weak acids only partially break down, giving less H+. example - acetic acid 2. Define + give an account of the term 'logP', explaining how this could be determined + its relevance to pharmacokinetics of a drug (6 marks) - logarithm of the octanol/water coefficient - log P gives an indication of a drugs permeability ( it is a factor within Lipinski's rule of 5 ) - log p > indicates lipophilic drug ....... - it is important to have a balance between the 2. if log p is too low (i.e. <3) may be too hydrophilic + be unable to penetrate cell membrane - if log p value is too high, the compound may be too hydrophobic + have poor aqueous solubility. the compound may also accumulate in cell membrane 3. Blinded trials: - research study in which the participants are unaware related to the study. this is done to minimise bias + ensure integrity of the results - there are 2 main types of blinded trials: - single-blind trial = in this type, the participants are unaware of which treatment they are receiving, while the investigators are aware - double-blind trials = both ..... - help prevent any conscious biases that could influence the results 1/1

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