Chemistry of Drugs PCCI Quiz

1. Which of the fol- most drug metabolism is carried out by the liver lowing statement - if the compound is orally delivered, enzymes in the are CORRECT when GI tract + lumen will start the process of metabolism considering drug metabolism? 2. Which of the following statements are CORRECT when considering aqueous solubility? - aqeous solubility increases as polarity increases - hydrophillic drugs have excellent aqeous solubility - Aqueous solubility decreases as the melting point of a compound increases 3. Which of the follow- NaOH ing compounds are - it is a strong base that accepts a proton UNABLE to behave as a Bronsted-Lowry acid? 4. Which statement is the pH of a solution is critical since it will dictate true when consider- whether a compound will be ionised or not ing partitioning, solubility + pH? 5. Which statement is charged compounds are far more soluble in polar soltrue when consider- vents than the uncharged equivalents ing partitioning, solubility + pH? 6. Which one of these is a weak acid? carbonic acid (H2CO3) 7. Which of the follow- excipients are pharmacologically active ingredients ing statement relating to pharmaceu( false as they are inert) tical formulation is FALSE? 8. Which of the follow- - the dose of most active pharmaceutical ingredients ing statement relat- (APIs) is too small to develop into dosage forms withing to pharmaceuout utilising excipients 1/5 tical formulation is TRUE? - a pharmaceutical formulation is a specific combination of API + excipients - the choice of dosage form is often dependent upon the water solubility of the API - the choice of dosage form is sometimes critical to ensure patient compliance 9. Which of the follow- the cost of the API ing is NOT a consideration when formulating a new API? 10. Which of the following is a consideration when formulating a new API? - hydrophobicity of the API - the susceptibility of the API to degrade in acidic conditions (stomach) - the degree of first pass metabolism - the stability of the API 11. Which of the fol- a divided powder is a multi-dose preparation lowing statements relating to enteral drug administration is FALSE? 12. Which of the following statements relating to enteral drug administration is TRUE? - enteral administration is non-invasive + convenient for the patient - oral powders, tablets + capsules are examples of enteral dosage forms - enteral administration is not appropriate for unconscious patients/those who are unable to swallow - enteral dosage forms also include liquid formulations (e.g. suspensions) 13. Regarding tablets, - a glidant (e.g. colloidal silica) can be used to increase which of the folthe palatability of tablets lowing statements if FALSE? Glidants are not typically used to enhance the palata2/5 bility of tablets; their primary function is to improve the flow properties of the powder blend during tablet manufacturing. 14. Regarding tablets, which of the following statement is TRUE? - tablets are simple to administer + can deliver an accurate dose - tablets come in many forms, including chewable, sublingual + enteric-coated varieties - a filler (e.g. lactose) can be added to increase the size of the tablet - disintegrants (e.g. starch) can be added to speed up the rate at which tablets break down into smaller fragments 15. Which of the follow- unlike emulsions, hydrolysis of the API in solutions is ing is FALSE when not a concern considering the use of oral solutions? 16. Which of the following is TRUE when considering the use of oral solutions? - oral solutions are absorbed faster than solid dosage forms - oral solutions are susceptible to microbial contamination - oral solutions are useful in young patients + those with difficulties swallowing - phase separation of oral solution is not a concern with solutions 17. In relation to suspen- A suspension is a liquid preparation containing 1 or sion, which of follow- more APIs dissolved in a suitable vehicle ing statement is INCORRECT? 18. Suspension: - in suspension, the API are not dissolved but rather dispersed in the vehicle - suspension involve solid particles suspended in a liquid medium 19. 3/5 In relation to suspen- - suspensions are useful for administering insolusion, which of the fol- ble/poorly water soluble drugs lowing statements is CORRECT? - in suspension, sedimentation can occur over time 20. In relation to suspen- suspensions are examples of stabilised oil-in-water sion, which of follow- dispersions ing statement is INCORRECT? 21. Which is advantage - fast onset of action of parental drug ad- - appropiate for unconscious patients ministration? - approp by patients who are 'nil by mouth' - not subject to first-pass metabolism 22. A semi-solid prepa- paste ration in which 1 or more APIs are incorporated in a base with large proportions of finely dispersed powder is termed a ...? 23. Which of the follow- nebulisers are only used in minor cases of respiratory ing statements is IN- diseases CORRECT concerning pulmonary (inhaled) drug delivery? 24. Which of the fol- a nebuliser is a device used to administer medication lowing statements is in the form of a liquid mist to the airways CORRECT concerning pulmonary (inhaled) drug delivery? 25. Which of the following statements is 4/5 CORRECT concern- metered dose inhalers can contain solutions, suspening pulmonary (in- sions/emulsions in mixture of inert propellants held haled) drug delivunder pressure ery? 26. Which of the folinhaled corticosteroids can cause mouth + tongue lowing statements is soreness, hoarseness of voice + oral thrush CORRECT concerning pulmonary (inhaled) drug delivery? 27. Which statement is INCORRECT? transdermal patches cannot produce a systemic effect 28. Which of the follow- the ames test is an example of an in vivo test to assess ing statements rea lead compound's mutagenicity garding preclinical testing is INCORRECT? 29. What is the purpose to refine hit series to develop more potent + selective of hit to lead optimi- compounds sation? 5/5