University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

130

Pages:

3
Author:

Sara

1. Which of the following statements describe the term 'bioavailability'? Fraction of the drug that reaches the systemic circulation 2. How selective a ligand is to a binding site: Specificity 3. The transfer of compounds in Distribution and out of the various tissues of the body: 4. Rate of elimination of the drug from the plasma: Clearance 5. Which of the following stateBlack triangle drugs are new mediments relating to the black trian- cines/vaccines that are under additional gle is CORRECT? training 6. Which of the following statements relating to adverse drug reactions and clinical trials is FALSE? A type C ADR includes reactions not observed until months/years following drug use 7. Complete the sentence: ' Phar- Adsorption macokinetics does NOT include ..' 8. Which of the following statements related to exposure is TRUE? Chronic exposure is considered to be repeated doses over a 1-month period 9. Which of the following facts re- An acidic drug will be mostly ionised in lating to physicochemical prop- the stomach meaning the stomach is the erties if FALSE? main site for absorption 10. Why is this statement incorrect - weakly acidic drugs are actually more - An acidic drug will be mostly likely to be absorbed in the small intestine ionised in the stomach meaning the stomach is the main site for absorption? 1/3 11. Which of the following is CORRECT? G protein alpha subunits? contain intrinsic GTPase activity 12. Why is this statement incorrect - isn't always reversible 'reversibly bind to beta gamma - when activated by a receptor, the alpha subunits'? subunit changes shape + separates from beta gamma complex to signal downstream - this bond is temporary 13. Why is this statement incorrect - usually amphipathic = have both hy'G protein alpha subunits are drophilic and hydrophobic regions highly hydrophilic'? - this amphipathic nature allows the alpha subunits to interact with both the hydrophilic environment inside the cell + hydrophobic environment at cell membrane where G protein-coupled receptors are located 14. Why is this statement incorrect - They do not contain intrinsic ATPase 'G protein alpha subunits con- activity tain intrinsic ATPase activity'? - instead, they contain GTPase activity - this GTPase activity allows the alpha subunit to hydrolyse GTP into GDP - the hydrolysis of GTP into GDP is essential for terminating the signal cascade initiated by GPCR 15. Which of the following statements describes an emulsion? An oil-in-water dispersion 16. What is emulsion? - Involves the dispersion of 1 immiscible liquid phase within another, like oil droplets in water - creates a 2 phase-liquid system 17. An acid is an electron-pair donor 2/3 In relation to acids and bases, which of the following statements is FALSE? 18. In relation to excipients used An example of a coloring agent is lactose in compressed tablets, which of the following statement is INCORRECT? 19. An example of a coloring agent - lactose is a type of sugar used as a filler is lactose - why is this incorrect + diluent in tablets statement? - coloring agents are substances added to provide color to the tablet 3/3