Drug Discovery & Sources of Drugs Part 2 | Cheat Sheet - Edubirdie

University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

6

Pages:

2
Author:

Sara

1. What were drugs like before the 20th century? - mainly potions and herbs - any toxicities were ignored + pharmacological actions were found accidentally 2. What does basic drug re- - potential drug targets, usually genes/ proteins search identify? 3. Why do scientists interfere to control / eliminate disease with drug targets? 4. Why do scientists conduct to optimise ADME in the body experiments on the compound? 5. How do pharmaceutical send all the data to the FDA in a new drug applicompanies get their drug cation (NDA), where the FDA make a decision on the market? on safety, efficiency and quality 6. Deine excipients: inactive substance performing as the medium for a drug 7. What do NICE decide They do a cost vs benefit analysis to decide about drugs that are whether the NHS should pay for novel drugs + successfully licensed and determine if it can be prescribed to patients reach the market? 8. What happens when patients run out? other companies can make + distribute the drug as generic drug 9. What are chemoinformat- computational methods to store & investigate ics? data to predicts the activity, toxicities + other properties of drugs 10. What is SAR? relationships between chemical structure + the resulting activity / toxicity 11. Define repositioning in chemo-informatics:: their efforts are shifted to finding new uses for existing drug compounds 12. 1/2 Chemoinformatics are used -------------- the drug process: 13. Define synthetic drugs: THROUGHOUT (not just in finding potent drugs / identifying toxicities) man-made from oil-based chemicals in a lab 2/2

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