University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

134

Pages:

2
Author:

Sara

5 phases 1. Drug discovery Describe the overview of the main phases and processes of drug discovery and drug development that are necessary to go from a therapeutic concept to a final product 2. Pre-clinical development 3. Clinical development 4. Approval 5. Phase IV in clincal What is done in the drug discovery phase? -Target idenification - Fins lead compounds - PK-profiling What happens in Pre-Clinical development? - PK - Toxicology - Formulation - Synthesis scale up How many phases are there in clinical development? 4 phases What happens in the first clinical phase? Investiagte - tolerability - Side effects Investogate - optimize dose/efficeny What happens in second clincal phase? - long-term side effects Large scale effect in a big population What happens in the third clinal phase? - placebo group After authorites approve the drug When does the fourth clinical phase happen? What is activity centered discovery? - post market surveillance Identifying compounds with desired biological effects without prior knowledge about the target 1/2 + broad discovery potential (idenfity novel compounds with unexpected mechanism of action) + Functional relevance (directly observing the compounds have a significant impact of the diseses) What are the pros and cons of activity centered discovery? - Mechsnim uncertainty - Potential off-target effects Examples of drugs from activty centered Penicillin salicsylic acid What is target centered discovery? Start with identification of a specific bilogical target in a diseses + mechinism insigt + precision + predicable What are the pros and cons of Target centered discovery? -limited by current knowledge - Does not bring new insigth of the disese Examples of drugs from target centered discovery? 2/2 Statins ibuprofen ACE- inhibtors Omeprazol