PCC1 - MCQ

1. In relation to excipients used in com- an example of distinegrant is lacpressed tablets, which one of the follow- tose ing statments is INCORRECT? 2. Which of the following statements, regarding protein binding, is INCORRECT? only bound drug is free to distribute into tissues 3. Which of the following statments describe bioavailability (F)? Fraction of the drug which reaches the systemic circulation 4. Which of the following statements describes affinity? how well a drug binds to a receptor 5. Which of the following factors does NOT crystallinity influence a compound's lipophilicity? 6. Which of the following statements regarding nicotinic receptors is TRUE? binding of acetylcholine to the nicotinic receptor allows passage of sodum ions into the cell + potassium ions out of the cell 7. Movement of drugs by passive diffusion requires the compound to be across biological membranes .... lipophilic 8. Which of the following sentences regarding enzyme inhibition is INCORRECT? non-competitive inhibition can be overcome by increasing the substrate's concentration ( inhibitor binds to the enzyme other than active site, altering the enzyme's conformation + reducing its activity) 9. Which of the following statements regarding myasthenia gravis is INCORRECT? this disease is due to the overexpression of nicotinic receptors at the neuromuscular junction 10. Which of the following statements de- <5 hydrogen bond donors, <10 scribes the criteria for Lipinski's rule of hydrogen bond acceptors, <500 5? molecular weight, logp <5 1/3 11. Complete this statement so that it is increasing hydrogen bonding CORRECT.. 'A compound's hydrophillcity increases with ..' 12. Which one of the following statements, the mechanism indicates the rate regarding organic chemistry reactions of the reaction is FALSE? 13. Regarding Type A ADR, which of the fol- commonly known as 'on-target lowing statements is CORRECT? toxicity' 14. Which of the following statements regarding drug toxicity is INCORRECT? Type B ADR are related to pharmacological action 15. In related to medicinal chemistry, what a secondary metabolite produced is a natural product? by an organism 16. Which of the following statements describe a suspension? a solid dispersed in a liquid continuous phase 17. Which of the following routes of adsubcutaneous ministration involves injecting a small amount of a solution / suspension under the skin? 18. Which of the following statements regarding preclinical testing is INCORRECT? the ames test is an example of an in vivo test to assess a lead compound's mutagenicity 19. Which of the following statements re- these evaluate the effectiveness garding Phase III clinical trials is COR- of the drug compared to standard RECT? treatments 20. Which of the following is INCORRECT regarding a drug with a log p value of 4.78? this drug is hydrophillic 21. the proability of this type of error occuring is expressed as the 'sig2/3 Which of the following statements is CORRECT regarding Type 1 errors in clinical trial design? 22. Which of the following is NOT a class of excipients commonly seen in tablet formulations? nificant of the result ' (e.g. p value < 0.05 indicates a significant result) preservatives 23. Which of the following is NOT a class of carboxylic acid natural product? 3/3