University:
University of Wolverhampton
Course:
4PY019 | Pharmacy
Academic year:

2024
Views:

384

Pages:

3
Author:

Sara

What is statine?Non-natural amino acid Non-natural amino acid contained within contained within pepstatin. pepstatin. Pharmacore The portion of a molecule that determines the biological effects of a drug Methylene Hydrophobic contributor used to increase chain/ring size and make it easier to cross membranes. Aromatic Type of ring that cannot be added to. Increased Effect of DB on metabolism of a drug. Double Bonds Used to change degrees of unsaturation. Decreased Effect of double bonds on flexibility. Increased Effect of double bond on potency of an analogue. Hard drug Resistent to metabolism Soft drug Predictable and controlled metabolism Hard handle Added to decrease a drug's metabolism. Stereocentre C-atom must be sp3 hybridised and have four different substituents. LogP Partition coefficient. 5 Lipinski's rules - H-bond donors. 500 Lipinskis rules - molecular weight. 5 Lipinskis rules - LogP 10 Lipinskis rules - H-bond acceptors 10 Lipinskis rules - rotatable bonds. pKa The pH at which the ratio of the molar ratio of a drug's acid to its conjugate base is 1:1. pH>pKa pH/pKa relationship where there is increased conjugate base formation. pH

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