Mechanisms of Fever - Edubirdie

University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

303

Pages:

2
Author:

Mariam A. A.

Infections ↓ micro-organisms ↓ have exogenous pyrogens ↓ eg. LPS viral RNA ↓ delecled on pattern recognition receptors such as toll like receptors on immune cells immune response Hyperthyro dom ↑mitochondrial ↓ ona dalius phosphorylation Imetabolism Post-Brain Injwy ↓ traumatic brain injury, inmacranial hemorrhage, brain tumars neurosurgical interventions act on organum vasculom of lamina terminalis IL-1, TNF-2, 12-6, IFNS → monocytes macophages preophic area of ant. hypothalamus thermogenesis direct damage to thermoregulatory neurons disruption of afferent! efferent pathways that regulale neat production dissipation neuroinflammatory cytokine release. Won-infecious inflammatory disease Kawasaki Disease, systemic. juvenile arthriks, SLE, Vasculitis, tumors →a circumventicular organ near the hypo-thalamus autoimmune COX-2 ↓ POE Hssue damage ◎ binds to E3-R in the hypothalamus raises thermostatic set point FEVER Ongs hapen-provien comdexes Creoanliges) bind to prokens recognised des foreign autonomic dysregulation SSRI amphetamines some drugs affect central neuro-Hansmitters Ce.g. dop, S-HT) ↑ dysregulated heat produchon neoplashic inflamm-abian PHYSIOLOGICAL IMPACTS OF FEVER CNS Cardiovascular Behavioural lethargy cogailue andrexia * confusion sleepiness * delirium social intercachon Melabolic ↓ ↑GMR ↓ *102 consumption *glucose utalisation *↑ prolien catabolism Fluid Glectrolyte Balance * vasodilation HOTN Losses Glectrolyte Imbalance 20 loss through skin respiration risk of dehydration Nat's it losseo may occur * con exacerbate underlying conditiamo eg, stung *↑ muscle tone activity

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