University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

195

Pages:

1
Author:

Mariam A. A.

IMMUNODEFICIENCY Acquired Malnutrition IV drug use HIV/AIDS Renal disease Trauma Immunosuppressants Corticosteroids Chemotherapy Viral infections Stress Congenital X-linked Mutations in the gene encoding the γ chain shared by 12-2, 12-4, IL-7, IL-9, IL-15 X-linked agammaglobulinemia-Bruton disease Mainly affects males Mutations in the gene that encodes tyrosine kinase ↓ signaling of tyrosine kinase Abnormal rise in development of thymus, parathyroid gland, portions of face, aortic arch, appendix, tonsils ↓ survival ↓ response to vaccination T-cell deficiencies ↑ susceptibility to Candida, Pneumocystis, CMV, Pseudomonas Hypocalcemia Parathyroid gland hypoplasia B-cell deficiencies Recurrent sinusitis, otitis media, pneumonia ↑ risk of autoimmune diseases ↓ response to vaccination Severe combined immunodeficiency (SCID) Due to continued depletion of cellular resources in infants ↑ susceptibility to opportunistic infections Death in infancy Di George Syndrome Development malformation of the 3rd & 4th pharyngeal pouches Abnormal thyme development