University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

46

Pages:

1
Author:

Mariam A. A.

Acute Therapy Diagram: A complex diagram illustrating the treatment options for acute migraines. The diagram includes various medications and their mechanisms of action. Arrows indicate the relationships between different treatment options. The diagram is color-coded for better organization. Text: 1st line: Triptans Sumatriptan Zolmitriptan Rizatriptan Naratriptan Frovatriptan Almotriptan Eletriptan Ergotamines Dihydroergotamine Ergotamine tartrate Work on 5-HT1-R Cause vasoconstriction Triptans Work on 5-HT1-R Cause vasoconstriction Also bind directly on trigeminal nerve endings Less likely to cause nausea Oral Subcutaneous Intranasal Prophylactic Therapy Preventative measures Lifestyle modifications Medications Antidepressants (TCAs) Amitriptyline Nortriptyline ↑ 5-HT ↓ NE Vasoconstriction CGRP antagonists Eranumab Fremanezumab Galcanezumab Bind on CGRP Prevent CGRP release Anticonvulsants Topiramate Valproate Reduce neuronal excitability Botulinum Toxin Type A Injections into the forehead Reduces muscle spasms Prevents headaches Beta-2 blockers Metoprolol Propranolol ↓ Vasodilation