University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

76

Pages:

1
Author:

Mariam A. A.

Renal Vascular Anatomy & Diseases Subtitles: Vascular anatomy of kidneys Regulation of BF (Blood Flow) Renal Vascular Diseases: macro & micro Nodes and Text: Role: Refer to mechanisms, but some extra notes. Tubules: Have no O₂ demand, as they reabsorb majority of filtered Na+. GFR: 60-120 ml/min → 120-240 L of glomerular filtrate per day. But urine volume: 1-2 L per day. Autoregulation: MD cells → specialized cells of distal tubules. SUS (Sympathetic Nervous System) + RAAS (Renin-Angiotensin-Aldosterone System) are never completely off. Tubuloglomerular feedback. ↑ Na+ → ↑ GFR due to pressure natriuresis. e.a. (Efferent arteriole) dilates to ↑ hydrostatic P. RAAS: e.a. more constricted than a.a. ↑ [angiotensin II] constricts a.a. to ↓ GFR in situations of chronic vol. depletion. Markers: Oliguria more sensitive marker than creatinine. How do vascular diseases of kidney present clinically? Secondary HTX due to RAAS activation from hypoperfusion. Renal impairment → ↓ BF → ↓ GFR.