University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

8

Pages:

1
Author:

Mariam A. A.

Cervical Neoplasm Transformation zone Sub-columnar reserve cells Normally mature cells stuck in G1 When cells grow faster than body needs Produce 2 new daughter cells Continue through cell cycle Basal layer of transformation zone Integrates its DNA into the host's DNA 66-67% of HPV types Tumor suppressor genes e.g., p53 HPV 16 is most common More than 100 types Not due to HPV Most common neoplasm of cervical intra-epithelial lesion Slow growth 10-20 years for cancer to develop Unwanted cell replication Resistant to apoptosis Dysplasia Cancer Cervical adenocarcinoma Endometrial glands of cervix Grading How much epithelium is involved GRADE 1 GRADE 2 GRADE 3 CERVICAL INTRA-EPITHELIAL NEOPLASIA IN SITU CARCINOMA INVASIVE CERVICAL CANCER Basal membrane Spread through cervical stroma Symptoms Abnormal vaginal bleeding Increased vaginal discharge Vaginal discomfort Unexplained weight loss Pain when urinating Pain during sex Spread beyond pelvic wall Bloody urine Rates 4th most common cancer in women Multiple partners Smoking Immunocompromised