University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

248

Pages:

1
Author:

Mariam A. A.

Muscle Relaxants 0.8-11 mg/kg Used in short procedures, setting where there's a need for muscle relaxation to avoid muscle tremor (e.g., during intubation) Onset: 1-2 min Duration: 30-90 mins MOA: Nicotinic receptor antagonist Non-depolarizing Given before surgery or during intubation Side Effects: Drowsiness, fatigue, dizziness, headache, dry mouth, autonomic cardiovascular effects Malignant hyperthermia Autonomic release of histamine Anaphylaxis Adverse Reactions: Myasthenia gravis Hypertension Hypokalemia Arrhythmias Contraction of individual myofibrils in an uncoordinated fashion Fasciculations Laryngospasm Apnea Neostigmine: Reverses the action of non-depolarizing muscle relaxants Onset: 1-2 min Duration: 1-2 hrs Mode of action: Cholinesterase inhibitor Suxamethonium: Depolarizing Short acting Rapid onset Short duration Side Effects: Fasciculations Myalgia Increased intragastric pressure Cardiovascular effects Histamine release Bronchospasm Flushing Itching