University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

460

Pages:

1
Author:

Mariam A. A.

Voltage Sensitive Sodium Channel Blockers Diagram: A mind map or concept map with various branches and sub-branches. Key terms and phrases are connected by lines or arrows. Colors are used to differentiate categories. Text: State-dependent More effective on depolarizing cardiomyocytes More effective when arrhythmia is severe More selective for abnormally active parts of the heart Most likely to cause arrhythmias → sudden death Classes: Class I ADRs (Adverse Drug Reactions) Hypotension Dry eyes Dry mouth People with heart failure have increased risk of ischemic effect Bradycardia Phase 0 of action potential Quinidine Procainamide Lidocaine Mexiletine Smaller change in slope of Phase 0 No effect on AP or refractory period Uses: Supraventricular tachycardia that progresses to ventricular fibrillation Refractory arrhythmias or arrhythmias that don't respond to other treatments Ischemic myocytes since they have trouble maintaining voltage conduction Class II β-blockers Longer phases 3, 2, and 4 Class III Amiodarone Dofetilide Sotalol Uses: Prevent V-tach A-fib in MT (Malignant Ventricular Tachycardia) Key: ↑ = increase ↓ = decrease QRS = QRS complex AP = action potential Refractory period