University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

347

Pages:

2
Author:

Mariam A. A.

Thiamine deficiency (Vitamin B1) Definition Leads to impaired glucose breakdown and damage to highly aerobic tissues Epidemiology • • One of the most common vitamin deficiencies in Australia Those who drink alcohol are under high risk Causes • • • • • Consider: - Increased needs - Low intake - Increased losses - Malabsorption Alcohol Malignancy Diarrhoea Bariatric surgery Pathophysiology Low B1 -> impaired glucose intake -> decreased ATP levels -> tissue damage -> primary affects aerobic tissues, such as the brain and heart Clinical features/Signs and Symptoms • • • • • • • Loss of appetite Fatigue Irritability Wernicke encephalopathy - Neurological syndrome - Nerve damage - Confusion Blurry vision Beriberi Nausea and vomiting Diagnosis • • • • • Physical exam History questions Muscle aches Thiamine loading test Full blood test Treatment • Supplements - Multivitamins • • - Vitamin B complex Improve diet - Nuts - While grains - Germ of cereals - Cauliflower - Liver - Egg noodles - Potatoes Treat underlying cause