University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

220

Pages:

1
Author:

Mariam A. A.

Pharmacology Basic Definitions Dosage • The size and frequency of a dose of a drug Bioavailability • The systematic available fraction of the drug First order kinetics • Rate of drug metabolism is proportional to drug in plasma Zero order kinetics • Rate of drug metabolism is constant and independent of drug concentration in the plasma Therapeutic window • Dosage with the greatest therapeutic benefit without a toxic effect Therapeutic window • Used to compare the therapeutically effective dose to the toxic dose of a pharmaceutical agent Half Life • Time required for the concentration to reach half of its’ original value CYP450 enzyme • • Catalyses the insertion of oxygen into C and H and N and H bonds Carries out phase one reactions in drug metabolism Single compartment model • • • Assumes drug can enter or leave Open model The whole-body acts as a single uniform Double compartment model • • Divides the body into central and peripheral compartments - Central: plasma and tissues where the distribution of drug is instantaneous Has two phases: - Alpha phase: rapid decline -> rapid distribution - Beta phase: metabolism and redistribution of drug between central and peripheral compartments