Renal Physiology Study Resources | Western Sydney University - Edubirdie

University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

459

Pages:

1
Author:

Mariam A. A.

Renal Physiology Filtration • Factors influencing GFR: - Obesity -> decrease GFR as the kidneys will need to work harder. - Hypertension - Meat consumption -> increase creatinine - although cigarette smoking causes a decrease in vascular resistance resulting in lower BP and higher GFR in the general population, chronic smoking lowers GFR through unknown mechanism(s) in a small subset of the population. - Body builders -> increased Cr Measuring GFR and RPF • • • 1) filtered through the glomerulus and not reabsorbed or (2) not filtered by the glomerulus but secreted in the tubular portion of the kidney. There is a polysaccharide called inulin, which is not normally found in humans, that is usually used to determine what the glomerular filtration rate is of the kidney. This is because it is freely filtered through the glomerulus but neither secreted nor reabsorbed by the tubular portion of the nephron. Therefore, the renal clearance of inulin is equal to the glomerular filtration rate of 125 mL/min. - The amount of inulin filtered per unit time = the amount of inulin excreted per unit time. Thus, insulin clearance is equal to the GFR. Another interesting substance is PAH (para-amino hippuric acid), which is freely filtered, fully secreted and not reabsorbed. This means that the renal clearance of PAH is equal to the renal plasma flow of 625 mL/min. (the amount of inulin that is delivered from the renal artery the tubules will secreted that into the tubule rather than reabsorbing it, into the interstium) Inulin clearance only reflects the volume of plasma that is filtered (GFR) and not that remains unfiltered (RBF) and get passes through the kidney.

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