Targeted Therapies for Cancer | Western Sydney University - Edubirdie

University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

175

Pages:

2
Author:

Mariam A. A.

MONOCLONAL ABS Rituximab: CD20 on B cells Type I CD20 antibody Activates complement system → holes in cells B cell depletion Used for CLL, NHL, autoimmune diseases (rheumatoid arthritis, vasculitis) Trastuzumab: Targets HER2 (Human Epidermal Growth Factor Receptor 2) Used for breast, gastric, ovarian cancers, lung cancer Adjuvant therapy for early-stage breast cancer Cetuximab: Targets EGFR (Epidermal Growth Factor Receptor) Used for metastatic colorectal cancer, non-small cell lung cancer, head and neck cancer Bevacizumab: Binds to VEGF (Vascular Endothelial Growth Factor) Anti-VEGF Inhibits tumor cell vascularization Blood supply to tumors Used for colorectal cancer, renal cell carcinoma, non-small cell lung cancer Imatinib: Small molecule tyrosine kinase inhibitor Targets BCR-ABL fusion protein Chronic myelogenous leukemia (CML) Side Effects: impaired wound healing, hemorrhage, hematuria, nasal bleed, hemoptysis, epistaxis, thrombosis, heart failure, cardiomyocyte damage, apoptosis, holes in cells Dasatinib, Nilotinib: Other mechanisms similar to Imatinib Target BCR-ABL kinase Sunitinib: Targets receptor tyrosine kinases (RTKs) Used for renal cell carcinoma, gastrointestinal stromal tumors, soft tissue sarcoma Sorafenib, Axitinib, Pazopanib: Other mechanisms similar to Sunitinib Target RTKs Erlotinib, Gefitinib, Afatinib: Target EGFR kinase Non-small cell lung cancer Side Effects: Cardiomyocyte damage Heart failure Fatigue Thrombocytopenia (low platelet count) Gastrointestinal symptoms Rash Neurologic symptoms Pulmonary toxicity

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