Chronic Myeloid Leukemia

CHRONIC MYELOID LEUKEMIA Genetics: 10% of cases BCR-ABL fusion gene (9:22) Associated with ONL (Oculo-Noto-Lymphoid) syndrome Symptoms: Bone pain Night sweats Fatigue Fever Weight loss Easy bruising Bleeding Anemia Thrombocytopenia Splenomegaly Extra-medullary hematopoiesis Risk of splenic rupture Pruritus (itchy skin) Skin rash Skin pigmentation changes Basophilia (increased basophils) Eosinophilia (increased eosinophils) Neutrophilia (increased neutrophils) WBC count Blast cells (10-19%) Refractory (doesn't respond to treatment) Still high through treatment Blast phase (transition to acute leukemia) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation p63 mutation Accelerated phase (disease progression) Blast cells (10-19%) Cell proliferation Apoptosis Granulocytes (10-19%) Histamines Chronic phase (no symptoms) Mild anemia Neutropenia Thrombocytopenia Rare: basophilia, eosinophilia 11q23 mutation