University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

58

Pages:

1
Author:

Mariam A. A.

DNA ALKYLATING AGENTS Uses: Hodgkin's lymphoma, non-Hodgkin's lymphoma, multiple myeloma, breast cancer, ovarian cancer, small cell lung cancer, neuroblastoma, retinoblastoma Mechanism of action: alkylates DNA, leading to cell death Side Effects: bone marrow suppression, nausea, vomiting, hemorrhagic cystitis, sterility, hair loss, teratogenic, carcinogenic Nitrogen Mustards: Cyclophosphamide, ifosfamide, melphalan Active forms: phosphoramide mustard, chlorambucil Cleavage of DNA Interstrand cross-linkage Side Effects: hemorrhagic cystitis, hematuria, nephrotoxicity, carcinogenic, bladder cancer Nitrosoureas: Carmustine, lomustine Temozolomide (compound with alkylating properties) Used for brain tumors, glioblastoma multiforme Side Effects: nausea, vomiting, seizures, headache, neurotoxicity Other alkylating agents: Dacarbazine Procarbazine Used for Hodgkin's lymphoma, melanoma Metabolized in liver Side Effects: nausea, vomiting, hematuria, nephrotoxicity, carcinogenic, bladder cancer