University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

319

Pages:

1
Author:

Mariam A. A.

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) Genetics: Chromosomal mutation Down syndrome Translocation (TEL-AML1, MLL gene) MLLt10, MLLt3, MLLt6, MLLt7, MLLt8, MLLt11, MLLt12, MLLt14, MLLt16, MLLt17, MLLt19, MLLt25, MLLt26, MLLt38, MLLt44, MLLt55, MLLt63, MLLt69, MLLt73 B-lymphoblasts: 20% of ALLs T-lymphoblasts: 80% of ALLs Treatment: Induction therapy Consolidation therapy Maintenance therapy Complications: Relapse Refractory (doesn't respond to treatment) Cellulitis UTI Anemia Thrombocytopenia Bleeding Bruising Fatigue Fever Weight loss Lymphadenopathy Hepatosplenomegaly Mediastinal mass Testicular enlargement Compression of SVC (superior vena cava) Compression of trachea, bronchi, esophagus Enlargement of neck, face, chest, arms Meninges Cranial nerve compression Headache Vomiting Seizures Papilledema Blurred vision Blindness Retinopathy Platelet count Bleeding Bruising Splenomegaly Lymphadenopathy Hepatomegaly Nausea Vomiting Anemia Thrombocytopenia Infection risk